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KMID : 1161520230270010260
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Animal Cells and Systems
2023 Volume.27 No. 1 p.260 ~ p.271
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Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice
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Moon Ha-Jung
Shin Hyun-Seung
Lee Seung-Hyun
Hong Eui-Ju
Ahn Chang-Hwan
Yoo Yeong-Min
Jeung Eui-Bae
Lee Geun-Shik
An Beum-Soo
Jung Eui-Man
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Abstract
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Bisphenol A (BPA) is a representative endocrine-disrupting chemical that exhibits hormonal disturbance reactions. Various alternatives, such as Bisphenol S (BPS) and Bisphenol F (BPF), are being developed. BPS and BPF (which are representative alternatives to BPA) are used in consumer products such as polycarbonate plastics and epoxy resins. They have structures similar to those of BPA and have also been proven to be exogenous endocrine disruptors. However, although there are many studies on BPA, there are few studies on the neurodevelopmental effects of BPS and BPF. Therefore, in this study, we analyzed neurobehavioral changes in offspring mice exposed to BPS and BPF during brain development by administering BPS and BPF to pregnant mice. We found that prenatal exposure to BPS and BPF did not affect anxiety-and depression-like behaviors, locomotion, sociability, memory, or cognition functions in offspring mice. However, exposure to BPS and BPF decreased the preference for social novelty in the offspring mice. Taken together, these findings suggest that perinatal exposure to BPS and BPF affects changes in social behaviors, but not other behavioral changes such as emotion, memory, or cognition in the offspring mice.
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KEYWORD
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Endocrine disrupting chemicals, BPS, BPF, brain development
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